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100% Non - Steroidal Anti - Inflammatory Analgesics Lornoxicam CAS 70374-39-9
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Detailed Product Description
| English Name: | Lornoxicam | CAS:: | 70374-39-9 |
|---|---|---|---|
| MF:: | C13H10ClN3O4S2 | EINECS:: | 630-354-7 |
| Other Name:: | Chlortenoxicam; Telos; Lorcam; 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide; Xefocam; | Appearance:: | Faint Yellow To Dark Yellow Solid Powder |
| Application:: | Treatment Of Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Gouty Arthritis And Tenosynovitis | Purity:: | >99% |
| PSA:: | 136.22000 | LogP:: | 3.38760 |
| Grade Standard: | Medicine Grade |
100% Non-steroidal Anti-inflammatory Analgesics Lornoxicam CAS:70374-39-9
| Product Name: | Lornoxicam |
| Synonyms: | LORNOXICAM;AKOS 93662;6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide;LornoxicaM for injection;6-Chloro-4-hydroxy-2-Methyl-N-2-pyridinyl-;LornoxicaM API;6-CHLORO-4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE;2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide,6-chloro-4-hydroxy-2-methyl-n-2-py |
| CAS: | 70374-39-9 |
| MF: | C13H10ClN3O4S2 |
| MW: | 371.82 |
| EINECS: | 630-354-7 |
| Product Categories: | API;AVITA;APIs;Inhibitors;Intermediates & Fine Chemicals;Other APIs;Pharmaceuticals;Sulfur & Selenium Compounds;Fused Ring Systems |
| Mol File: | 70374-39-9.mol |
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| Lornoxicam Chemical Properties |
| Melting point | 225-230°C (dec.) |
| storage temp. | -20°C Freezer |
| solubility | DMSO: >5mg/mL (warmed) |
| pka | pKa2 4.7(at 25℃) |
| form | powder |
| color | faint yellow to dark yellow |
| Merck | 14,5582 |
| CAS DataBase Reference | 70374-39-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,T+ |
| Risk Statements | 36/37/38-28 |
| Safety Statements | 26-36-45-36/37-28 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | 3 |
| RTECS | XJ9095000 |
| HazardClass | IRRITANT |
| PackingGroup | II |
| HS Code | 29349990 |
| Toxicity | LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss) |
| MSDS Information |
| Lornoxicam Usage And Synthesis |
| Description | Lornoxicam (Trade name: “Xefo”) belongs to a non-steroidal anti-inflammatory drug. As a kind of oxicam class drug, it has analgesic, anti-inflammatory and antipyretic properties. It can be used for the treatment of various type of acute mild to moderate pain which results from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and rheumatic diseases. Lornoxicam is capable of potently inhibiting the prostaglandin biosynthesis process, making it have highly pronounced efficacy. The exact mechanism of Lornoxicam is not exactly understood. However, it is indicated that Lornoxicam can inhibit the prostaglandin and thromboxane synthesis by inhibiting both COX-1 and COX-2, leading to reduction of inflammation, pain, fever, and swelling. |
| References | https://www.drugbank.ca/drugs/DB06725 https://en.wikipedia.org/wiki/Lornoxicam |
| Chemical Properties | Crystalline Solid |
| Uses | keratolytic, antiacne, antineoplastic |
| Uses | ocular vasoconstrictor |
| Uses | For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases. |
| Uses | Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic |
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