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Pharmaceutical Intermediates Famotidine CAS 76824-35-6 Histamine H2 Receptor Blocker
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Detailed Product Description
| English Name: | Famotidine | CAS:: | 76824-35-6 |
|---|---|---|---|
| MF:: | C8H15N7O2S3 | EINECS:: | 616-396-9 |
| Other Name:: | Ifada; Gaster; Famotidine; Fibonel; | Appearance:: | White Solid |
| Application:: | Histamine H2 Receptor Blocker | Purity:: | >99% |
| PSA:: | 235.25000 | LogP:: | 3.11400 |
| Grade Standard: | Medicine Grade |
Pharmaceutical Intermediates Famotidine CAS 76824-35-6 Histamine H2 Receptor Blocker
| Product Name: | Famotidine |
| Synonyms: | aminosulfonyl)-;dispronil;famodil;famosan;famoxal;fanosin;fibonel;ganor |
| CAS: | 76824-35-6 |
| MF: | C8H15N7O2S3 |
| MW: | 337.45 |
| EINECS: | 616-396-9 |
| Product Categories: | Histamine receptor;Amines;Heterocycles;Sulfur & Selenium Compounds;LODINE;Other APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API's |
| Mol File: | 76824-35-6.mol |
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| Famotidine Chemical Properties |
| Melting point | 163-164°C |
| density | 1.5111 (rough estimate) |
| refractive index | 1.7400 (estimate) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | Very slightly soluble in water, freely soluble in glacial acetic acid, very slightly soluble in anhydrous ethanol, practically insoluble in ethyl acetate. It dissolves in dilute mineral acids |
| form | neat |
| pka | pKa 6.76(H2O t=23.0) (Uncertain) |
| Water Solubility | 1.1 mg/mL |
| InChIKey | XUFQPHANEAPEMJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 76824-35-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 20/21/22-45-61 |
| Safety Statements | 22-24/25-53-45-36/37/39 |
| WGK Germany | 2 |
| RTECS | UA2300000 |
| HS Code | 29341000 |
| Hazardous Substances Data | 76824-35-6(Hazardous Substances Data) |
| Toxicity | LD50 i.v. in mice: 244.4 mg/kg (Yasufumi) |
| MSDS Information |
| Provider | Language |
|---|---|
| Famotidine | English |
| SigmaAldrich | English |
| Famotidine Usage And Synthesis |
| Description | Famotidine (Chemical formula: C8H15N7O2S3; Brand Name: PEPCID) belongs to a histamine H2-receptor antagonist. It appears as a white to pale yellow crystalline compound. Inside the body, its primary activity is inhibiting the gastric secretion process, further reducing the acid concentration and volume of gastric secretion in the stomach. Based on this property, it is used for the treatment and prevention of ulcers occurring in the stomach and intestines. It can also treat diseases such as Zollinger-Ellison syndrome in which the stomach accumulates excess amount of acids. Moreover, it is also applied during the treatment of gastroesophageal reflux disease (GERD) and pathological hypersecretory conditions. |
| Reference | http://www.rxlist.com/pepcid-drug/clinical-pharmacology.htm https://en.wikipedia.org/wiki/Famotidine |
| Description | Famotidine is a competitive histamine H2-receptor antagonist, and the main pharmacodynamic effect of famotidine is to cause the inhibition of gastric secretion. Famotidine on decomposition releases toxic products such as carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), and sulphur oxides (SO2, SO3). Famotidine is a medication that is available both in prescription and over-the-counter forms. It is used to treat conditions related to the oesophagus, stomach, and intestines. Some specific famotidine is used for the treatment of duodenal ulcers, gastric ulcers (stomach ulcers), gastroesophageal reflux disease (GERD), and pathological hypersecretory conditions that occur when stomach acid is secreted/ produced in very large quantities, an abnormal health condition called ‘Zollinger-Ellison syndrome’. |
| Chemical Properties | White Powder |
| Uses | Histamine H2-receptor antagonist. Antiulcerative. |
| Uses | antiinflammatory |
| Uses | For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). |
| Uses | Use as an H2-antagonist. An anti-ulcer agent |
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