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English Name: | Omeprazole | CAS:: | 73590-58-6 |
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MF:: | C17H19N3O3S | EINECS:: | 615-996-8 |
Other Name:: | LOSEC; Zimor; [14C]-Omeprazole; ANTRA; | Appearance:: | White Solid |
Application:: | Treatment Of Pepticulcer, Reflux Esophagitis | Purity:: | >99% |
PSA:: | 96.31000 | LogP:: | 3.76540 |
Grade Standard: | Medicine Grade | ||
High Light: | pharmaceutical industry raw materials,medicine raw material |
Omeprazole CAS 73590-58-6 ,Treatment Of Pepticulcer, Reflux Esophagitis
Product Name: | Omeprazole |
Synonyms: | 1h-benzimidazole,5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulf;2-Chloromethyl-3,5-dinmethyl-4-methoxypyridine;5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazol;audazol;aulcer;belmazol;ceprandal;elgam |
CAS: | 73590-58-6 |
MF: | C17H19N3O3S |
MW: | 345.42 |
EINECS: | 615-996-8 |
Product Categories: | Metabolite Reference Standard;Isotopically Labeled Pharmaceutical Reference Standard;OSMITROL;Other APIs;Digestive System;Drug bulk;Active Pharmaceutical Ingredients;Omeprazole;Intermediates & Fine Chemicals;Pharmaceuticals;API's;ATPase |
Mol File: | 73590-58-6.mol |
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Omeprazole Chemical Properties |
Melting point | 156°C |
Fp | 9℃ |
storage temp. | 2-8°C |
solubility | H2O: 0.5 mg/mL |
form | solid |
pka | pKa 4.14/8.9(H2O,t =25,I=0.025) (Uncertain) |
color | white |
Water Solubility | Soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml). |
Merck | 14,6845 |
Stability: | Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark. |
InChIKey | SUBDBMMJDZJVOS-UHFFFAOYSA-N |
CAS DataBase Reference | 73590-58-6(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xi,T,F |
Risk Statements | 36/37/38-39/23/24/25-23/24/25-11 |
Safety Statements | 26-36-37/39-45-36/37-16-7 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 2 |
RTECS | DD9087000 |
HS Code | 29333990 |
Hazardous Substances Data | 73590-58-6(Hazardous Substances Data) |
Toxicity | LD50 in mice, rats (g/kg): 0.08, >0.05 i.v.; >4, >4 orally (Ekman) |
MSDS Information |
Provider | Language |
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5-Methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-3H-benzoimidazole | English |
SigmaAldrich | English |
Omeprazole Usage And Synthesis |
Uses | Omeprazole is a proton pump inhibitor used to treat diseases like gastroesophageal reflux disease (GERD), used for gastric and duodenal ulcers, reflux or erosive esophagitis, and Zollinger-Ellison syndrome. It is also effective for gastric and duodenal ulcers that are ineffective with H2 receptor antagonists. Injections of Omeprazole can also be used for: 1 gastrointestinal bleeding, such as peptic and anastomic ulcer bleeding, and the prevention of severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and gastric surgery caused by upper intestinal bleeding; 2 acute gastric mucosal damage complicated by stress or nonsteroidal anti-inflammatory drugs; 3 general anesthesia, post-surgery, or coma patients, to prevent acid reflux and aspiration pneumonia; 4 Combined with amoxicillin and clarithromycin, or with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp). |
Mechanisms of Action | Omeprazole is a proton pump inhibitor which can specifically act on gastric parietal cell proton pump sites and transform into the active form of sulfonamide, then irreversibly binds to the proton pumps through disulfide bonds, generating a sulfonamide and proton pump compound (H + -K + -ATP), thereby inhibiting the enzymatic activity, preventing the H+ in parietal cells from being transported to the stomach cavity. It has a strong and persistent inhibitory role on gastric acid secretion caused by basal gastric acid and pentapeptide gastric acid secretions, greatly reducing gastric acid within the gastric juice. Rapid, reversible, and no H2 antagonist-induced psychiatric side effects. |
Drug Interactions |
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Adverse reactions | Omeprazole is well tolerated, and most adverse reactions are mild and reversible.
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Preparation |
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Chemical Properties | White Crystalline Solid |
Uses | Binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative |
Uses | diuretic, sweetener, diagnostic aid |
Uses | A selective proton pump and CYP inhibitor |
Uses | Omeprazole Pellets are used in the treatment of Gastroesophageal reflux disease (GERD): A condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus) |