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Anti - Allergic Antipruritic Raw Material Medicine Cyproheptadine CAS 41354-29-4

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Anti - Allergic Antipruritic Raw Material Medicine Cyproheptadine CAS 41354-29-4

China Anti - Allergic Antipruritic Raw Material Medicine Cyproheptadine CAS 41354-29-4 supplier
Anti - Allergic Antipruritic Raw Material Medicine Cyproheptadine CAS 41354-29-4 supplier Anti - Allergic Antipruritic Raw Material Medicine Cyproheptadine CAS 41354-29-4 supplier Anti - Allergic Antipruritic Raw Material Medicine Cyproheptadine CAS 41354-29-4 supplier

Large Image :  Anti - Allergic Antipruritic Raw Material Medicine Cyproheptadine CAS 41354-29-4

Product Details:

Place of Origin: china
Brand Name: cyproheptadine
Certification: GMP
Model Number: pr-3015

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Price: Negotiable
Packaging Details: 10kg/ bag
Delivery Time: 3~5 week days after payment
Payment Terms: Western Union, T/T, MoneyGram,
Supply Ability: 10000kg/month
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Detailed Product Description
English Name: Cyproheptadine Hydrochloride CAS:: 41354-29-4
MF:: C21H24ClNO EINECS:: 623-762-1
Other Name:: Cyproheptadine Hydrochloride Sesquihydrate; Cyproheptadine Hydrochloride; Appearance:: White To Slightly Yellowish Crystalline Solid
Application:: Anti-allergic/antipruritic Raw Material Medicine Purity:: >99%
PSA:: 12.47000 LogP:: 5.37350
Grade Standard: Medicine Grade

Anti-allergic/Antipruritic Raw Material Medicine, Cyproheptadine CAS 41354-29-4
 

Product Name:Cyproheptadine hydrochloride
Synonyms:CYPROHEPTADINE HCL;CYPROHEPTADINE HYDROCHLORIDE;CYPROHEPTADINE HYDROCHLORIDE HYDRATE;CYPROHEPTADINE HYDROCHLORIDE SESQUIHYDRATE;4-(5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDINE)-METHYLPIPERIDINE HYDROCHLORIDE;CYPROHEPTADINE HCL USP(CRM STANDARD);CYPROHEPTADINE HYDROCHLORIDE EPC(CRM STANDARD);CyproheptadineHclUspGrade
CAS:41354-29-4
MF:C21H22ClN
MW:323.86
EINECS:623-762-1
Product Categories:Building Blocks;Heterocyclic Building Blocks;API;PERIACTIN;Piperidines
Mol File:41354-29-4.mol
Cyproheptadine hydrochloride Structure
 
Cyproheptadine hydrochloride Chemical Properties
Melting point165 °C (dec.)(lit.)
solubilityethanol: soluble
formsolid
colorwhite to slightly yellow
λmax285nm(0.05mol/L H2SO4)(lit.)
Merck14,2773
CAS DataBase Reference41354-29-4(CAS DataBase Reference)
 
Safety Information
Hazard CodesXn
Risk Statements22-36/37/38
Safety Statements26-36
RIDADRUN 2811 6.1/PG 3
WGK Germany3
RTECSTM7050000
HazardClass6.1
PackingGroupIII
HS Code29333990
ToxicityLD50 orally in mice: 74.2 mg/kg (Loux)
 
MSDS Information
ProviderLanguage
SigmaAldrichEnglish
 
Cyproheptadine hydrochloride Usage And Synthesis
AntihistaminesCyproheptadine hydrochloride is a kind of pipecolic antihistamines,it can compete with histamine released from the organization for H1 receptor on effector cells , thereby it can prevent the onset of an allergic reaction, and release histamine-induced spasm and congestion effects, this product has a strong H1 receptor antagonism, its anti-histamine effect is stronger than chlorpheniramine, promethazine . There are mild to moderate anti-serotonin effects and anticholinergic effects. In addition, there is a stimulate appetite effect, and weight gains after a certain time.
Clinically cyproheptadine hydrochloride is mainly used for acute and chronic urticaria (especially it has a good effect on cold urticaria ), papular urticaria, angioedema, atopic eczema, contact dermatitis, food allergy, drug allergy, allergic rhinitis, hay fever, allergic conjunctivitis, allergic to insect stings and migraine. It has some therapeutic effect on bronchial asthma . It is acceptable for the adjuvant treatment of Cushing's syndrome, acromegaly. In addition,as an appetite enhancer,it is used for neuropathic fear of food. There are reports about acanthosis nigricans treatment, prevention of necrotizing pyoderma.
【Dosage 】oral often release dosage : (1) allergic diseases: adult, once 2~4mg, one day 2 or 3 times. (2) Cushing's syndrome, applicable to the treatment of cases of bilateral adrenal hyperplasia,it can inhibit the hypothalamic release of corticotropin releasing hormone (CRH) and inhibit the secretion of pituitary adrenocorticotropic hormone (ACTH), thereby lowering plasma ACTH and cortisol levels; adults start one day 8mg,which can be gradually increased to one day24mg; the usual dose is one day 12~24mg, divided doses,it needs long-term use; in the case of cortical function inadequate after total resection or subtotal bilateral adrenal, on one hand ,supple corticosteroids, on the other hand,take cyproheptadine,which can reduce the chance of occurrence of pituitary tumors.
The above information is edited by the chemicalbook of Tian Ye.
UsesAnticoagulant, anti-allergic drugs. It can be used for urticaria, eczema, and allergic contact dermatitis, skin itching and other allergic reactions. It can also be used for Cushing's diseases and acromegaly.
Chemical PropertiesWhite or slightly yellow, crystalline powder.
UsesH1-antihistamine, antipruritic
UsesCyproheptadine is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Cyproheptadine is a 5-HT2/5-HT1C serotonin receptor antagonist; H 1 histamine receptor antagonist; antipruritic.

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