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Pharmaceutical Raw Materials,L-carnitine CAS 541-15-1,Nutrition Supplements

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Pharmaceutical Raw Materials,L-carnitine CAS 541-15-1,Nutrition Supplements

China Pharmaceutical Raw Materials,L-carnitine  CAS 541-15-1,Nutrition Supplements supplier
Pharmaceutical Raw Materials,L-carnitine  CAS 541-15-1,Nutrition Supplements supplier Pharmaceutical Raw Materials,L-carnitine  CAS 541-15-1,Nutrition Supplements supplier Pharmaceutical Raw Materials,L-carnitine  CAS 541-15-1,Nutrition Supplements supplier Pharmaceutical Raw Materials,L-carnitine  CAS 541-15-1,Nutrition Supplements supplier

Large Image :  Pharmaceutical Raw Materials,L-carnitine CAS 541-15-1,Nutrition Supplements

Product Details:

Place of Origin: china
Brand Name: L-Carnitine
Certification: GMP
Model Number: pr2112

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Price: Negotiable
Packaging Details: 25kg/barrel
Delivery Time: 3~5 week days after payment
Payment Terms: T/T,
Supply Ability: 100000kg/month
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Detailed Product Description
English Name: Carnitine CAS:: 541-15-1
MF:: C7H15NO3 EINECS:: 208-768-0
Other Name:: (R)-carnitine;karnitin; ST 198; L-Carnitine Inner Salt; Carnitene; Appearance:: White Crystal Or Transparent Powder
Application:: For Medicines, Nutraceuticals, Functional Drinks, Feed Additives Purity:: >99%
PSA:: 60.36000 LogP:: -1.80650
Grade Standard: Medicine Grade,Food Grade,Feed Grade
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Pharmaceutical Raw Materials,L-carnitine Cas 541-15-1,Nutrition Supplements

 

Product Name: L-carnitine
Synonyms: VITAMIN B-GAMMA;VITAMIN BT;VITAMIN BT INNER SALT;VITAMINE BT;(-)-carnitine;(3-carboxy-2-hydroxypropyl)trimethyl-,hydroxide,innersalt,l-ammoniu;(3-carboxy-2-hydroxypropyl)trimethyl-,hydroxide,innersalt,L-Ammonium;(3-carboxy-2-hydroxypropyl)trimethyl-ammoniumhydroxide,innersalt
CAS: 541-15-1
MF: C7H15NO3
MW: 161.2
EINECS: 208-768-0
Product Categories: pharmaceutical chemicals;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis, food additives, pharmaceuticals;Inhibitors;FINE Chemical & INTERMEDIATES;Miscellaneous;chiral;Amino Acids;Ammonium Polyhalides, etc. (Quaternary);Quaternary Ammonium Compounds;L-Carnitine Series;Vitamins and derivatives;Food Additives;Aliphatics;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File: 541-15-1.mol
L-carnitine Structure
 
L-carnitine Chemical Properties
Melting point 197-212 °C(lit.)
alpha -31 º (c=10, H2O)
Boiling point 287.5°C (rough estimate)
density 0.64 g/cm3
refractive index -32 ° (C=1, H2O)
storage temp. 2-8°C
solubility H2O: 0.1 g/mL at 20 °C, clear, colorless
form Crystals or Crystalline Powder
pka 3.80(at 25℃)
color White
PH 6.5-8.5 (50g/l, H2O)
Water Solubility 2500 g/L (20 ºC)
Merck 14,1849
BRN 4292315
Stability: Hygroscopic
CAS DataBase Reference 541-15-1(CAS DataBase Reference)
 
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS BP2980000
F 3-10
Autoignition Temperature >365 °C
Hazard Note Irritant
HS Code 29239000
Hazardous Substances Data 541-15-1(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
 
MSDS Information
Provider Language
L(-)-Carnitine English
SigmaAldrich English
ACROS English
ALFA English
 
L-carnitine Usage And Synthesis
Indications and Usage Carnitine is a type of vitamin B, and its structure is similar to that of amino acids. It is mainly used to help transport long-chain fatty acids to provide energy and to prevent fat from collecting in the heart, liver, and skeletal muscles. Carnitine can prevent disordered fat metabolism due to diabetes, fatty liver disease and heart disease, and it can reduce heart damage, lower blood triglyceride, aid in weight loss, and increase the antioxidant effects of vitamin E and C. Meats and giblets are high in carnitine. Artificially synthesized carnitine includes L-carnitine, D-carnitine, and DL-carnitine, and only L-carnitine has physiological activities. On the other hand, D-carnitine and DL-carnitine competitively inhibit the activity of carnitine acetyltransferase (CAT) and carnitine palmitoyltransferase (PTC) to prevent cells’ fat metabolism, thus harming human nutrition. L-carnitine was first discovered in 1905 by Russian chemists Gulewitsch and Krimberg in infusion broth, and its chemical structure was determined in 1927 by Tomita and Senju. L-carnitine is a white crystalline or transparent powder, and its melting point is 200℃ (decompose). It is easily soluble in water, lye, methanol and ethanol, barely soluble in acetone and acetate, and insoluble in chloroform. It is hygroscopic. L-carnitine can be used as an animal nutrition enhancer, and it is mainly used to enhance protein-based food additives to promote fat absorption and utilization. L-carnitine also is a nutrition enhancer that is mainly used in soy-based infant foods, sports nutritional foods and weight loss foods to promote fat absorption and utilization. According to China’s regulations, the permitted amount in biscuits, drinks, and dairy beverages is 600-3000mg/kg; in solid beverages, liquids, and gel capsules, 250-600mg/kg; in formula, 300-400mg/kg; in infant foods, 70-90mg/kg (1g tartrate is equivalent to 0.68g l-carnitine). L-carnitine can also be used as an appetite booster. L-carnitine affects the elimination and utilization of ketone bodies, so it can be used as a biological antioxidant to eliminate free radicals, maintain membrane stability, increase animal immunity and resistance to disease and stress. Oral L-carnitine can increase the speed of sperm maturation and sperm vitality, it can increase the number of forward-moving sperm and motile sperm in oligospermia and asthenospermia patients, thus increasing the women’s clinical pregnancy rate, and it does so safely and effectively. L-carnitine can bind with organic acids and the large amounts of acyl coenzyme derivatives produced in children with fatty acid metabolism disorder and turn them into water soluble acylcarnitine to be excreted through urine. This not only aids in controlling acute acidosis occurrences, but also effectively improves long-term prognosis.
Mechanisms of Action L-carnitine cannot participate in protein biosynthesis, but it promotes ketone body utilization and nitrogen generation to an extent. Its main function is to promote fatty acid beta oxidation, which occurs in the liver and the mitochondria of other tissue cells. It is known that free fatty acids and acyl coenzyme A cannot penetrate the inner mitochondrial membrane, but acylcarnitine can do so swiftly. Thus, it is determined that L-carnitine is the carrier that transports fatty acid and acyl forms into the mitochondrial membrane. The mechanisms of this transporting process are still unknown, but it is certain that carnitine acyl-CoA transferase is the key enzyme in this process. It has two isoenzymes, one of which is carnitine acyl-CoA transferase I, positioned on the outer side of the membrane. When fatty acid is catalyzed by acyl-CoA-synthatase to produce acyl-CoA, it is transported by carnitine acyl-CoA transferase I into the membrane. After it has entered the membrane, it is catalyzed by the second isoenzyme - carnitine acyl-CoA transferase II – to turned into a form of acyl-CoA that can be directly utilized by fatty acid catabolic enzymes. Afterwards, it releases energy through processes such as dehydrogenation and deoxygenation.
L-carnitine can also adjust the acyl ratio in mitochondria, thus affecting energy metabolism. L-carnitine can participate in the transportation of branched chain amino acid metabolites, which encourages the regular metabolism of branched chain amino acid.
Pharmacokinetics L-Carnitine is very easily soluble in water, and can be entirely absorbed by the human body when consumed through food. It is known that the small intestine absorbs L-carnitine, but there is little known about the specific absorption process of carnitine (free or esterified) through intestine mucosa and about the specific absorption area. Besides external food sources of carnitine, humans can also synthesize carnitine with their own bodies. The liver and kidneys are mainly responsible for synthesizing carnitine. They progress from lysine into epsilon beta hydroxy three methyl lysine, and use aldolase and aldehyde oxidase to transform it into L-carnitine. Besides lysine, the body’s biosynthesis of L-carnitine also requires methionine, vitamin C, nicotinic acid and vitamin B6.
A rat dissection showed that carnitine is most concentrated in the adrenal gland, followed by the heart, bones, muscles, fat tissue, and liver, and the carnitine concentration in the kidneys and brain are 40 times that in blood. Human carnitine concentration has varied greatly due to inconsistencies in measuring method and test subject. The biological method of testing human blood carnitine content placed it between 0.86-2.87mg/100ml, and the enzymology method of testing muscle carnitine content placed it between 0.457-2.479μg/g. The absorbed carnitine is metabolized by the human body and excreted in urine as free carnitine.
Chemical Properties White or almost white, crystalline powder or colourless crystals, hygroscopic.
Uses antimethemoglobinemic, cyanide antidote
Uses Essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations f ound in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.
Uses Carniking(R) is a product for premix- and feed industry. It is particularly recommended for the enrichment of compound feed.
Uses L-Carnitine is a natural, vitamin-like nutrient wich plays an important role inhuman metabolism. It is essential in the utilization of fatty acids and in transporting metabolic energy
Uses Natrulon(R) RC-100 is 100% L-Carnitine. This white crystalline powder, highly hygroscopic and amino acid like material brings not only the exfoliation but also, an additional benefit of a high level of moisturization capability.
Uses Natrulon(R) RC-50DG is a 50% solution of L-Carnitine in decaglycerol/water. Natrulon(R) RC-50DG to provide a truly multi-functional product: an exfoliating product with excellent moisturization capability.

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