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2-Bromo-1 , 3-Thiazole Raw Pharmaceutical Materials Anticholinergic Intermediate

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2-Bromo-1 , 3-Thiazole Raw Pharmaceutical Materials Anticholinergic Intermediate

China 2-Bromo-1 , 3-Thiazole Raw Pharmaceutical Materials Anticholinergic Intermediate supplier

Large Image :  2-Bromo-1 , 3-Thiazole Raw Pharmaceutical Materials Anticholinergic Intermediate

Product Details:

Place of Origin: china
Brand Name: 2-bromo-1,3-thiazole
Certification: GMP
Model Number: pr2110

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Price: Negotiable
Packaging Details: 25kg/barrel
Delivery Time: 3~5 week days after payment
Payment Terms: T/T,
Supply Ability: 10000kg/month
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Detailed Product Description
English Name: 2-bromo-1,3-thiazole CAS:: 3034-53-5
MF:: C3H2BrNS EINECS:: 221-229-4
Other Name:: 2-Bromothiazole; 2-bromo-thiazole; 2-BroMothiazole; Bromothiazole; 2-Thiazolyl Bromide; Appearance:: Colorless Transparent Liquid
Application:: Organic Synthesis Intermediate Purity:: >99%
PSA:: 41.13000 LogP:: 1.90560
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Antibiotic Raw Material 2-Bromo-1,3-Thiazole,Anticholinergic Intermediate

 

Product Name: 2-Bromothiazole
Synonyms: 2-THIAZOLYL BROMIDE;2-BROMOTHIOAZOLE;2-BROMOTHIAZOLE;2-BROMO-1,3-THIAZOLE;TIMTEC-BB SBB003918;2-bromo-thiazol;2-Bromothiazole, 98+%;Thiazole, 2-bromo-
CAS: 3034-53-5
MF: C3H2BrNS
MW: 164.02
EINECS: 221-229-4
Product Categories: ThiazolesHeterocyclic Building Blocks;Halides;Heterocycles;Thiazoles, Isothiazoles &Benzothiazoles;API intermediates;Organohalides;Thiazole;Heterocyclic Compounds;Thiazoles;Sulfur & Selenium Compounds;Thiazoles, Isothiazoles & Benzothiazoles;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Building Blocks;C3 to C7;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;alkyl bromide
Mol File: 3034-53-5.mol
2-Bromothiazole Structure
 
2-Bromothiazole Chemical Properties
Melting point 171 C
Boiling point 171 °C(lit.)
density 1.82 g/mL at 25 °C(lit.)
refractive index n20/D 1.593(lit.)
Fp 146 °F
storage temp. 2-8°C
form Liquid
color Clear colorless to orange-brown
Water Solubility insoluble
BRN 105724
InChIKey RXNZFHIEDZEUQM-UHFFFAOYSA-N
CAS DataBase Reference 3034-53-5(CAS DataBase Reference)
NIST Chemistry Reference Thiazole, 2-bromo-(3034-53-5)
EPA Substance Registry System Thiazole, 2-bromo-(3034-53-5)
 
Safety Information
Hazard Codes Xi,F
Risk Statements 36/37/38
Safety Statements 23-24/25-36-26
RIDADR 1993
WGK Germany 3
TSCA Yes
HazardClass IRRITANT, FLAMMABLE
HS Code 29341000
 
MSDS Information
Provider Language
2-Bromo-1,3-thiazole English
SigmaAldrich English
ACROS English
ALFA English
 
2-Bromothiazole Usage And Synthesis
Description It is usually used as the intermediate or raw material to produce various products in the organic synthesis and pharmaceutical industry, such as 2-acetylthiazole, antibiotics, and anticholinergic drugs. Specifically, this chemical can act as the raw material to produce camalexin through reaction with indolylmagnesium iodide.1 Moreover, this substance has been selected as the reactant to prepare the thiazole Grignard reagents and thiazolyllithium compounds, which can be converted into thiazole-2-carboxylic acid via a halogen-metal exchange reaction.2, 3 In addition, 2-bromothiazole has been used to synthesize N-aryl aminothiazoles, which are found to function as the inhibitors of cyclin-dependent kinases.4 Besides, this compound may be involved in the synthesis of ethynylthiazoles that exhibits a desirable anti-inflammatory activity.5
Referrence
  1. Ayer, W. A.; Craw, P. A.; Ma, Y. T.; Miao, S. C., SYNTHESIS OF CAMALEXIN AND RELATED PHYTOALEXINS. Tetrahedron 1992, 48, 2919-2924.
  2. Kurkjy, R. P.; Brown, E. V., THE PREPARATION OF THIAZOLE GRIGNARD REAGENTS AND THIAZOLYLLITHIUM COMPOUNDS. J. Am. Chem. Soc. 1952, 74, 6260-6262.
  3. Beyerman, H. C.; Berben, P. H.; Bontekoe, J. S., THE SYNTHESIS OF THIAZOLE-2-CARBOXYLIC AND OF THIAZOLE-5-CARBOXYLIC ACID VIA A HALOGEN-METAL EXCHANGE REACTION. Recl. Trav. Chim. Pays-Bas-J. Roy. Neth. Chem. Soc. 1954, 73, 325-332.
  4. Misra, R. N.; Xiao, H. Y.; Williams, D. K.; Kim, K. S.; Lu, S. F.; Keller, K. A.; Mulheron, J. G.; Batorsky, R.; Tokarski, J. S.; Sack, J. S.; Kimball, D.; Lee, F. Y.; Webster, K. R., Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977.
  5. Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V., Synthesis and anti-inflammatory activity of ethynylthiazoles. Khim. Geterotsiklicheskikh Soedin. 2006, 769-774.
Chemical Properties Colourless Liquid
Uses Aryl halide used to N-arylate 5- and 7-azaindoles.1 Copper-catalyzed cyanation provides 2-cyanothiazole.2
Uses 2-Bromothiazole is a heterocyclic S compound to induce base-pair substitution and having mutagenic activity.

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